W222402
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W222402
Aldrich
Caffeine
FCC, Kosher
| Synonym: | 1,3,7-Trimethylxanthine |
| CAS Number: | 58-08-2 |
| Linear Formula: | C8H10N4O2 |
| Molecular Weight: | 194.19 |
| FEMA Number: | 2224 |
| Beilstein Registry Number: | 17705 |
| EC Number: | 200-362-1 |
| Council of Europe no.: | 11741 |
| MDL number: | MFCD00005758 |
| PubChem Substance ID: | 24900939 |
| Flavis number: | 16.016 |
Description
| Packaging | Packaged in glass bottles |
| Biochem/physiol Actions | A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms. |
| F&F Certificates | Allergen Statement |
| EU Natural Certificate | |
| GMO Statement | |
| HALAL Statement | |
| Continuing Guarantee Statement | |
| US Natural Certificate |
Properties
| grade | FCC |
| Halal | |
| Kosher | |
| NI | |
| mp | 234-236.5 °C(lit.) |
| Gene Information | human ... ADORA1(134), ADORA2B(136), ADORA3(140), PDE4B(5142) |
| rat ... Adora1(29290), Adora2a(25369) | |
| mouse ... Adora2b(11541) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN1544 6.1/PG 3 |
| WGK Germany | 1 |
| RTECS | EV6475000 |
References
| reference | Hadfield, M.G., Caffeine and the olfactory bulb. Mol. Neurobiol. 15, 31-39, (1997) |
| Ferre, S., et al., Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 20, 482-487, (1997) | |
| Shafer, S.H., et al., Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. Biochem. Pharmacol. 56, 1229-1236, (1998) | |
| Islam, M.S., et al., In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation. Proc. Natl. Acad. Sci. U. S. A. 95, 6145-6150, (1998) | |
| He, A.W., and Cory, J.G., p53-independent anisomycin induced G1 arrest and apoptosis in L1210 cell lines. Anticancer Res. 19, 421-428, (1999) | |
| Poe, B.S., and O'Neill, K.L., Caffeine modulates heat shock induced apoptosis in the human promyelocytic leukemia cell line HL-60. Cancer Lett. 121, 1-6, (1997) | |
| Takagi, M., et al., DNA damage-associated cell cycle and cell death control is differentially modulated by caffeine in clones with p53 mutations. Leukemia 13, 70-77, (1999) | |
| Merck | Merck 13,01636 |
| Merck 13,1636 | |
| Beilstein | Beil. 26,00 |
| Beil. 26,461 / Beil. 26,IV,2338 | |
| Aldrich MSDS 1, 343:A / Corp MSDS 1 (1), 664:C / FT-IR 1 (2), 710:B / FT-IR 2 (3), 3668:B / IR-Spectra (2), 1120:B / IR-Spectra (3), 1287:D / NMR-Reference 2 (2), 586:A / RegBook 1 (2), 2467:A / Sax 6, 615 / Sigma FT-IR 1 (1), 581:A / Structure Index 1, 390:E:3 | |
| Arctander, 558 / FT-IR 1 (2), 710:B / Fenaroli, 228 / RegBook 58 (2), 2467:A / Structure Index 1, 390:E:03 |
